RESEARCH PROJECTS

While surgery continues to be the cornerstone of definitive treatment for thoracic malignancies such as esophageal and lung cancer, metastasis  the leading cause of death for these patients. There is an abundance of clinical evidence demonstrating that post-operative complications and acute systemic inflammation are associated with decreased disease-free survival in patients undergoing a wide variety of oncologic. The cellular players responsible for this phenomenon are only now coming to light and our laboratory has been a pioneer in establishing the role of neutrophils in this process.

 

Neutrophils are the key cellular mediators of acute systemic inflammation and have evolved a wide array of mechanisms to carry out their function. Most recently, we have demonstrated that circulating tumor cells (CTC) can adhere directly over arrested neutrophils in metastatic sites such as the liver and that this occurs in a cell adhesion molecule dependent fashion. Furthermore, we have shown that acute inflammation causes the release of neutrophil extracellular traps (NETs) in the microvasculature of host organs such as the lungs and liver and that these NETs facilitate cancer cell arrest and promote metastatic outgrowth. NET release (NETosis) is a recently described mechanism utilized by neutrophils to fight microbial infections. In an afflicted host, neutrophils can extrude their intracellular DNA in a web-like fashion into the microvasculature of an infected organ.

 

Our research has shown that these NETs can also trap circulating cancer cells and in fact promote their growth into gross metastasis. Recent developments in neutrophil biology have shown that NETs can also be induced by sterile inflammation such as that induced by local trauma or even by inflammatory agents secreted by a primary malignancy.

 

The primary focus of our lab is aimed at understanding what molecular mechanisms are responsible for NET/CTC interactions. We also wish to elucidate if tumor-bearing individuals are prone to NET formation and if this phenomenon has prognostic significance. If this is the case, NET based interference may be a valuable clinical therapy to limit metastatic spread from the time of diagnosis up to and including the treatment phase (surgery, radiation and chemotherapy) where patients are prone to acute inflammatory events. Preliminary data suggest that this process is likely conserved across numerous solid tumor sites with propensity for hematogenous spread. Hence, this type of therapy could have far reaching implications for cancer patients. Our goal is for these investigations to yield entirely novel clinical trials in the coming years.

Dr. Jonathan Spicer

Jonathan
Spicer

Principal Investigator
MD, PhD

Dr. Spicer was born and raised in Montreal and completed his Bachelor degree in Science at McGill University. He continued his medical training at McGill where he earned his MD, after which he moved to Vancouver and completed his surgical internship at the University of British Columbia. He returned to McGill the following year and completed his general surgical training during which he participated in the Surgeon Scientist and Clinical Investigator programs as an FRSQ funded student and earned a PhD in Experimental Surgery.

 

Dr. Spicer completed his training in Cardiothoracic Surgery at the world’s largest cancer center – University of Texas, MD Anderson Cancer Center in Houston. His clinical interests focus on minimally invasive approaches to lung cancer as well as complex resections for advanced thoracic malignancies. He has paired his clinical focus with a comprehensive research program in cancer metastasis. His laboratory studies the link between inflammation and metastasis with a particular focus on neutrophil and circulating tumor cell interactions.

 

Research interests:

Neutrophil based mechanisms of cancer metastasis, inflammation and cancer, thoracic malignancy clinical trials, airway surgery, thoracic trauma.

PRESENTATIONS

AWARDS

2015

 

Carolyn Reed President’s Award for best oral presentation,

Southern Thoracic Surgical Association

Orlando, Florida

 

 

2013

 

Top ten cancer discoveries in Canada

 

Top ten scientific publications in Quebec

 

 

2012

 

Canadian Institute of Health Research - Institute of Cancer Research
Publication Prize

 

 

2011

 

First Place for Committee on Trauma Video Competition

97th Annual Clinical Congress, American College of Surgeons

San Francisco, California

 

Best Basic Science and People’s Choice Awards

L.D. Maclean Resident Research Day

Department of Surgery, McGill University

 

 

Enhanced recovery pathways for esophageal cancer surgery

Quebec PeriAnesthesia Nursing Assocation

Laval, Quebec, May 2016

 

Neutrophils and liver metastasis: Friend or foe?

Canadian Surgical Forum

London, Ontario, September 2011

 

Neutrophils are key mediators of hepatic metastasis for Lewis lung carcinoma cells

Canadian Association of General Surgeons Resident Research Retreat

Victoria, British Columbia, September 2009

 

Resident Wellness

International Medical Graduate Orientation Day

Faculty of Medicine, McGill University, June 2009

 

Inflammation in early cancer cell metastasis to the liver

Metastasis and Angiogenesis Research Group

McGill University, February 2009

VIEW PUBLICATIONS

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Contact Ms. Betty Giannias
Email
514-934-1934 ext. 76102